Manchester City striker Sergio Aguero has suffered a serious muscle tear to his hamstring.
Aguero was stretchered off with a hamstring problem during the first half of Thursday's 2-0 defeat to Ecuador.
"The studies we did today show that Sergio Aguero has a grade-two muscle tear," the Argentine Football Association said in a statement on Friday.
Argentina ruled Aguero out of next week's World Cup qualifier against Paraguay but did not speculate how long he would be sidelined for.
However, a grade-two tear to the hamstring can require anything from two to eight weeks to recover from and the striker has a history of hamstring problems.