The Dutch ace is a target for United manager Sir Alex Ferguson.
And Hull City boss Bruce told talkSPORT: If he [Ferguson] gets him [Van Persie], it would be a wonderful signing.
"He's playing at the peak of his career and, with Manchester City laying down the gauntlet, it's the next challenge.
"Chelsea have been there and Arsenal have been there against them and now they see City as a big threat and you need people like him to come in to the team to freshen it up. There is no doubt about his quality.
"It would be mouthwatering if you've got van Persie and [Wayne] Rooney in the same team. That would be a wonderful combination.
"Van Persie played on his own last year. He virtually played as a lone striker, which would let Wayne just drift into that little position he takes up."