Cisse, capped 41 times by his country, had originally called time on his playing career in October 2015 due to a debilitating hip injury but hoped to resurrect his career after having an operation on the problem last year.
He trained with his first club Auxerre in a bid to get fit and earn a contract at a team in his native France but, after failing to attract any suitors, decided to call it quits on his 17-year career.
"I have loved being a footballer. Up until now, the ball was my whole life. I would have liked to have continued my career, which was interrupted in spite of me, but I have to admit today that football is finished," Cisse told Yahoo Sport - where he is set to work as a pundit.
"I'm going to give myself body and soul to my career as a DJ, a producer, and as a pundit, as well as develop my line of clothing."