The Germans host the Red Devils at BayArena on Matchday 5 of the Champions League and their Finnish boss suggests there could be a slight upset on the cards.
"At home we always play well," Hyypia told reporters. "Of course we want to win [but] it is not only an important game for us.
"We have to work defensively and offensively as a team. Then we have a chance."
Leverkusen sit second on the Group A table on seven points, one behind group leaders United, and two ahead of third-placed Shakhtar Donetsk who host Real Sociedad in the penultimate group stage match.
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball