The Belgian had made just one appearance since mid-November due to a troublesome hamstring problem but came off the bench to play the final 25 minutes of Monday's goalless draw at Southampton.
Neville told evertontv: "It was great to see him [Mirallas] back. It showed when Kevin came on, when their defenders dropped off a little bit, that they knew there was a player with pace.
"He brought others into the game. I thought Victor Anichebe made a huge change as well, causing them problems, and that was important for us."