Everton defender Phil Jagielka must undergo surgery on a badly gashed ankle.
The England international was injured in a challenge from Adam Le Fondre in the opening minutes of Everton's 3-1 win over Reading on Saturday at Goodison Park.
He had to be immediately replaced, and Moyes said: "I genuinely haven't seen it again but I thought on the pitch it didn't look good.
"Jagielka knew about it and it is a bad one. He will have surgery tonight to stitch up his ankle.
"It is a bad one because he is a key player for us."