The Arsenal star reacted angrily after being squirted from a drinks bottle by Kevin Mirallas as the players walked off at the break.
England midfielder Wilshere grabbed the back of the Everton man's neck and the pair started scuffling.
Players from both sides piled in and separated them, keeping them apart as they went down the tunnel.
In a clear dig at Wenger, Everton boss Moyes said: "I didn't see it," before adding: "I know somebody who says that quite a lot."
Was Moyes out of order? Or did Wenger have that one coming? Give us your shout below...