Both Liverpool and Tottenham failed to take advantage of scoring first as the Reds went down 3-2 at Anfield to Udinese, Spurs drew 1-1 away to Panathinaikos but Newcastle had a comfortable 3-0 home success over Bordeaux.
Tottenham paid the price for not making their dominance count in Greece as a late Panathinaikos strike denied Spurs the three points in a 1-1 draw.
A first-half header from captain Michael Dawson put the Londoners in the driving seat until Spanish striker Toche levelled with 13 minutes remaining finally giving some impetus to the Panathinaikos cause.
Spurs then had to endure a nervy last few minutes as the Greek side poured forward for the winner, but Tottenham held out and are still seeking their first Europa League win in Group J.
Inter Milan maintained control of Group H with a comfortable 3-1 win in Azerbaijan against Neftchi, all the Italian goals arriving in the first half from Brazilian Philippe Coutinho, Joel Obi and Marko Livaja with Colombian Fredy Guarin provider for all three.
Nicolas Canales responded with a 53rd-minute consolation for the hosts.
Lazio, with no great conviction, struggled to their first win in Group J – Brazilian Ederson hitting the only goal of the game in the 62nd minute against Maribor at the Stadio Olimpico, who had Jovan Vidovic sent off late on.
Last year's runners-up Athletic Bilbao went down 3-1 at Sparta Prague. Tomas Zapotocny, Bekim Balaj and Josef Husbauer scored for the home side, with Oscar De Marcos replying late for the Spaniards.
The Swiss champions fell behind just after the hour to a penalty after creating chances of their own, and in chasing an equaliser conceded a second to the Cameroon international in the final minute.
A seven goal thriller in Israel saw French side Lyon finally take the points with a late winner in a 4-3 success against Hapoel Kiryat Shmona.
Shimon Abuhatzira gave the hosts an early lead before Fofana, Fabian Monzon and Anthony Reveillere put Lyon ahead at the break.
But Hapoel fought back to level with strikes from Lior Levi and Abuhatzira only for Fofana to strike deep into injury time.
Newcastle eased to a first Group D win by beating Bordeaux 3-0 AT St James’ Park, ending the French clubs 17 game unbeaten run.
The game was over as a contest by the 49th minute as the Magpies raced into a three goal lead starting with Shola Ameobi in the 16th minute.
The hosts had fortune on their side when Bordeaux defender Henrique diverted a Danny Simpson cross into his own net, and the scoring was complete as Papiss Cisse added a third from an offside position.
An own goal by Sebastian Coates and a low strike by Giovanni Pasquale in quick succession gave Udinese a two goal cushion and even though a Luis Suarez free-kick gave the Brendan Rodgers outfit hope, Liverpool slumped to their third home defeat in a row.
In Group B Atletico Madrid waited until the third minute of added time before scoring the only goal of the game at the Vocente Calderon for a 1-0 victory over Plzen, Cristian Rodriguez converting.