Tottenham, Celtic and Birmingham all lost their Europa League games leaving their progression in the competition hanging by a thread.
Spurs went down 2-1 at home to 10-man PAOK Salonika on a controversial night at White Hart Lane.
The home side went two goals down, pulled a goal back and then thought they had equalised through Jermain Defoe in the second half, but referee Bas Nijhuis penalised the striker for a foul.
Tottenham now need to win against Shamrock Rovers in Ireland in a fortnight's time and hope PAOK overcome Rubin Kazan in Thessaloniki.
An Arda Turan strike in the 29th minute was enough to give Atletico Madrid a 1-0 victory over Celtic at Parkhead.
Birmingham missed a first-half penalty then conceded the only goal of the game shortly after the break for a 1-0 defeat at Braga.
The Blues can still qualify if they beat Maribor at home next month.
Rubin Kazan 4-1 Shamrock Rovers, GpA
Haedo Valdez Oman 12
10, 51
Natcho 36
Martins 62
Braga 1-0 Birmingham, GpH
Viana 51
Celtic 0-1 Atletico Madrid, GpI
Turan 30
FC Metalist Kharkiv 4-1 Austria Vienna, GpG
Devic 17 Mader 19
Lacerda Edmar 40
Gueye 60
Sosa 89
Malmo 0-0 AZ Alkmaar, GpG
NK Maribor 3-4 Club Brugge, GpH
Volas 11 , 68 Donk 90
Hoefkens og51 Dirar 74 , 77
Akpala 81
Rennes 0-0 Udinese, GpI
Legia Warsaw 0-3 PSV Eindhoven, GpC
Zewlakow og 32
Mertens pen 60
Labyad 68
Rapid Bucharest 1-3 Hapoel Tel-Aviv, GpC
Deac 43 Nosa Igiebor 12
Tamuz pen 40
Toama 45
Standard Liege 2-0 Hannover 96, GpB
Tchite 25
Cyriac 59
Tottenham 1-2 PAOK Salonika, GpA
Modric pen 39 Salpingidis 6
Athanasiadis 13
Vorskla Poltava 1-1 FC Copenhagen, GpB
N'doye og 31 N'doye 37
