The Turkish side saluted 2-0 at home last week but the Italians made it more difficult at home, in front of an empty Stadio Olimpico in Rome as they served the second of their two-match stadium ban.
Senad Lulic have Lazio hope when he powerfully nodded home Antonio Candreva’s rightwin cross following a quickly-taken free-kick on the hour-mark.
That gave Lazio the impetus to push for a second goal but that determination in attack led to them conceding in the 73rd minute through Caner Erkin who hammered home Pierre Webo’s layoff to send the Turks through to the semi-finals.
2012/13 UEFA Europa League quarter-final – second leg
Stadio Olimpico, Rome – 1,000