Simao has not made Pochettino's squad for the past three games.
"I do not know if he will leave the club, I cannot see inside his head," the coach explained.
"Everyone takes their own decisions depending on their own personal situation and he has said nothing to me.
"During the four years that I have been here I have always said the same thing.
"Anyone that does not like it or does not want to be part of the dynamic and discipline then they know full well that the doors are open for them, whoever they may be."