The Arsenal youngster suffered a hairline fracture in his left foot during the 1-0 friendly win over Denmark on Wednesday night and is set to be sidelined for up to six weeks.
The injury has the remainder of Wilshere's Premier League season in tatters and could massively impact his chances of making England's World Cup squad for this summer's tournament in Brazil.
Hodgson offered his sympathy to both Wilshere and the Gunners, saying he feels sorry for the former Bolton loanee who continues to have a horror run with injuries.
"It's always sad when you have a player come from a club, use him on international duty and he gets an injury," he told Sky Sports News at the annual London Football Legends Awards in aid of the Willow Foundation.
"It's very sad and disappointing for Jack and Arsenal but unfortunately these things happen.
"It was an honest challenge but he took a nasty kick and I can only hope he recovers as early as possible."
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