Along with Rickie Lambert, Luke Shaw and Adam Lallana, there is uncertainty over the futures of Dejan Lovren, Jay Rodriguez, Calum Chambers, James Ward-Prowse, Victor Wanyama, Nathaniel Clyne, and Jose Fonte.
The England boss sympathises with their position.
"It is a pity for Southampton," he said.
"But there are always big fish in the sea and it is hard to keep those fish away sometimes.
"We have got good players and I am afraid they are always going to gravitate towards the big clubs."
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