Real coach Carlo Ancelotti started the game with Luka Modric in midfield and Iker Casillas was recalled in goal.
Ronaldo connected with a beautiful back-heeled pass from Benzema and put in a low hard shot that the outstretched Claudio Bravo couldn't get a hand to. The Real ace celebrated his goal by facing the home crowd and asking them to take it easy.
The goal came as some relief to the Catalan club, one of the few moves that Luis Enrique's men managed to execute in the first half of the game.
After the break, Barca took control of the game ten minutes on as Uruguayan Suarez latched onto a spectacular ball from Dani Alves to slot home after 56 minutes.
Barça looked the better side in the second half, cutting through the Madrid defence with ease.
Neymar came close on a number of occasions, shooting over the bar after a mazy run from the half-way line before placing his shot wide of Casillas' left-hand post after a pass from Messi.