Eintracht Frankfurt fear Real Madrid recalling Jesus Vallejo in January.
The hamstring injury suffered by Pepe on Saturday saw the Portuguese ruled out for up to six weeks, with fellow centre-back Sergio Ramos already on the sidelines.
That currently leaves Raphael Varane and Nacho Fernández as Zinedine Zidane's only recognised senior alternatives at the heart of Los Merengues' defence.
Bild says Madrid could bid to bolster their rearguard depth in January by bringing Jesús Vallejo back early from his year-long loan at the club.