Aguero limped out of City's 6-3 victory over Arsenal last weekend with a calf injury and could be missing for two months.
Dzeko said: "Sergio has had an amazing season, scoring a lot of goals, and he is an important player for us.
"That's life, and now we have to try to play games without him, and try to win. This is very bad for the team but there are a lot of players who want to play."
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