Atletico have lodged a formal complaint to FIFA over Barca's public pursuit of Antoine Griezmann.
Simeone said on Thursday: "The complaint of Atlético? The club defends itself in the best way, seeking the best for the institution.
"Did I talk to him? Can he be affected? I see him involved. The other day, he forced himself to play against Alavès when he was not 100%.
"He is good with his teammates. I trust him."