With a trip to Barcelona looming on Tuesday, the Italian realises the need to rotate his squad.
And that should mean the return of £50million record signing Fernando Torres, who remained on the bench throughout Wednesday night's 1-0 win, and probably Michael Essien, Florent Malouda, Soloman Kalou and Jose Bosingwa.
"We will have to assess the players but there is a good chance some fresh ones will come in," said Di Matteo.
"Also, they deserve to be in the team as well.
"I left a few players out against Barcelona because I have to make decisions.
"We will see about Saturday but I have it in mind to give one or two a start."