Defoe's 45-minute run-out was his first since recovering from the ankle surgery that had sidelined him for two months.
"It's amazing really," said the 28-year-old, who replaced Aaron Lennon as Tottenham went for broke.
"Aaron said after the game, 'Were you tired?', and I said, 'Not at all'.
"I put all the work in on the rehab stuff, so I knew I'd be ready.
"The ankle feels good, which is always nice, and it was a great result."
He added: "I've been out such a long time. I couldn't wait just to get on and to get that buzz playing football again.
"Hopefully, I made an impact, helped the boys win the game.
"But second half was a great performance from all the lads."
Describing the pain of missing out on a historic few weeks for Spurs, which also included a Champions League win over Inter Milan, Defoe told BBC Sport: "I was out for nine, 10 weeks. It was hard; towards the end, I was getting really frustrated.
"But it's important to keep your head, make sure you come back, and make sure you come back strong so you can make an impact."