Spurs need a draw against Panathinaikos to be sure of progress to the next round.
“We always have fantastic support and that helps the lads to perform,” Defoe told the club's website.
“The European nights are special and there is so much history here.
“We want to get through to the knockout stage of the competition and as we’ve said all along, we want to do something special this season. Things are going well at the moment and we've just got to keep it going.”