Swansea were defeated by Hull City on the weekend.
De Guzman said: "We're not safe.
"It's a big blow. It's a game we have to learn from and take the positives and negatives to work on for next week.
"It's important not to look at the bottom teams, but to look at ourselves and getting the results we need.
"Even if we win one more, we can't assume that 36 points will do it. We've got to take every game as a final and try and get as many wins as we can."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball