The sides meet in Wednesday's third-round replay at Old Trafford after Robin van Persie rescued a 2-2 draw in the first game with a superb injury-time equaliser.
De Gea told MUTV: "We conceded two goals from headers in the first game and it's a type of play that you come across in this league quite a bit.
"But we have players at the back who are perfectly capable of dealing with the threat of big powerful strikers who like the ball in the air. We have enough nous to cope with that.
"It's something we work on and try to come up with solutions in training."