The Argentine ace is out of Saturday's Manchester derby with crosstown rivals Manchester United due after copping a three-match suspension for elbowing West Ham United's Winston Reid in the last round of Premier League matches.
Ahead of the Old Trafford clash, Belgian playmaker De Bruyne told Sky Sports that Pep Guardiola's City have the attacking qualities to cover the absence of such a player as Aguero.
"Obviously it's a blow. He's our main striker but you have to adapt to it," he said.
"We have loads of players waiting for that chance.
"It is not the same without Aguero, but we can play a good game.
"It's a shame for us, but this is the way it goes, we still have 50-60 games after for him to score goals."