Spurs played twice at the San Siro during their memorable run in the Champions League in the 2010-11 campaign, including Gareth Bale's famous hat-trick in a 4-3 defeat to Inter in October, 2010.
"We all know how tough it is in the San Siro and one thing is for sure, they won't lie down," Dawson told the Spurs website.
"There is a lot of pride at stake and I'm sure they will be hurting after losing 3-0 like they did at the Lane. We have to be ready for that.
"We're in a great position, don't get me wrong and we now have to go there, do a professional job and if we do that, we'll be okay. It won't be a walk in the park though, that's for sure."