Upson, 28 - he won the last of his seven international caps in November 2004 - returns to St Andrew's today for the first time since his £6million switch to the Hammers.
"Where we are blessed in this country in that we have fantastic central defenders. Really good ones.
"The most important thing for Matt is to remain fit and get over his serious injury."
Bruce believes Upson has been forgiven for leaving the club in the lurch.
He said: "At the time I was disappointed. It was the timing, more than anything. It was the last day of the transfer window and I couldn't bring in anyone else.
"But, looking back, it was the right thing because Matt was injured and we took the money.
"Our fans are a hard lot to call but I think he will get an OK reception. We got a hefty profit and he did extremely well for us."