Suarez is expected to be sold to Barcelona after his latest biting controversy.
Comolli, who was instrumental in the £25m deal to sign Suarez in January 2011, told BBC Radio 5 live: "Who do you replace him with? There is nobody like him around. If there was, Real Madrid and Barcelona would go after them and not Suarez."
Former Tottenham and Saint-Etienne sporting director Comolli also warned that rival clubs could use Suarez's ban to negotiate a cut-price deal.
He said: "If there was a buying club and they felt Liverpool would sell, they will take advantage and try to drive the price down."
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