The Reds striker has been involved in a number of controversies since joining from Ajax in 2011.
"It'll be an absolute shame for English football if this victimisation drives him away," Comolli told BBC Sport.
"As the biggest league in the world you want to keep the biggest players, not drive them away for crazy reasons."
Comolli was responsible for bringing the 25 year old to Anfield and believes the public and media should focus their attention on his talent.
"I find it extremely hard to understand why people look at all the bad aspects and not how good the player is," said the 40-year-old, who was sacked by Liverpool in April 2012.
"He is a fantastic individual and professional - totally committed to his club, team-mates and job. He'll give you everything, he's a winner.
"People need to be very careful what they say and stop criticising him. He's someone you'd want to go to war alongside. I don't think you can captain Ajax as a foreigner at 21 years of age if you're not a great individual."