The exhibition game, which was as a celebration of Chicago midfielder Cuauhtemoc Blanco, who played 333 games for Club America before coming to Major League Soccer, ended in a 2-1 victory for the visitors.
It took less than two minutes for Club America to make their mark through a Juan Carlos Silva strike.
Pavel Pardo made it two for Club America just before the break.
Chris Rolfe was able to pull one back for Chicago in the middle of the second half but Club America held on to secure the victory.