Midfielder Lampard said: "It is a blow for John personally and for the team because he is an inspirational player and a fantastic centre-half.
"He is a top player and experienced in these qualifying games.
"We saw his ability through the Euros in the summer and the other night and a big player, you always miss.
"But it's squad football and we are fortunate enough to be blessed with fantastic back-up, good centre-halves like Cahill and Jagielka.
"Whoever comes in are experienced top players. Whenever you lose a big player, you need the squad to step up and do the business and I'm sure we've got that."