Drogba looks certain to start for the first time since suffering a sickening head injury more than a month ago.
"In terms of fitness, he is ready," Villas-Boas said of the striker, who marked his comeback against Swansea on Saturday with a goal after coming off the bench.
"He's on top form, so he's available for selection. We just have to decide what we want strategically for the game."
"He'll be up for selection," said Villas-Boas.
"He's, of course, a player we trust."