The Ivory Coast hitman is available to face Atletico Madrid after serving his three-match Champions League ban.
But he picked up a minor leg injury at Bolton on Saturday and boss Carlo Ancelotti will monitor him before deciding whether to unleash the striker at the Vicente Calderon.
Ancelotti said: "Drogba had a little problem with his leg and we have to wait. I would like to change something.
"We have fresh players in good condition and I want to use all the players."