The Champions League title-holders travel to Prague for the Round of 32 first leg with Benitez eyeing the prize in Europe's second tier club competition.
"This is a massive city, massive club and a massive competition," Benitez said.
"We are really pleased to be here. Obviously, you cannot change things. The Champions League is a massive competition, but the Europa League is also a massive competition.
"We play against an historic team. We're really pleased and, for me, I try to give my players the right message. We know it will be tough."