Chelsea captain John Terry and Ashley Cole are out of England's World Cup qualifier against Belarus.
Captain Terry has failed to recover from his back problem, and Cole is out with a sore hamstring.
Terry was absent from Saturday's 5-1 win against Kazakhstan at Wembley - which continued England's perfect start of three straight wins from three fixtures in their 2010 qualifying campaign.
"It's disappointing to lose two very experienced players in John Terry and Ashley Cole for the game in Belarus," said coach Fabio Capello.
"Unfortunately they have no chance of playing, so it is best they return to Chelsea."