Despite needing the points to stay in touch in the race for the top four positions, Chelsea showed an alarming lack of fight in the game.
There were passages where they barely made an effort to win the ball back from City. And Wise was not pleased with the substitutions.
"Hazard is not a centre-forward, I don't believe," Wise told Premier League Daily on Sky Sports.
"Maybe he [Conte] felt against Barcelona they did well in that system, he felt it could work against City. It didn't.
"When you know it's not working you expect a change around 50 minutes to change the way your team is playing and that was the disappointing this about it, in the manner the substitution came on.
"You've got two strikers sitting on the bench ready to come on and all of a sudden you put one on in 80 minutes and another on in close to 90 minutes to affect the game. You can't do that.
"I think it was wrong in the way they set their stall out and the way they played. It was against a great team and you might as well go down and go down at least having a go."