Belgium will be without Thibaut Courtois and Marouane Fellaini for Tuesday's friendly with Russia.
The Chelsea goalkeeper and Manchester United midfielder have both been withdrawn due to injuries after playing in the 1-1 World Cup qualifying draw with Greece on Saturday.
Courtois has a hip injury while Fellaini is out with a toe problem.
It is expected that both players will be available for their respective clubs when the Premier League returns to action next weekend.
The key pair join fellow Premier League stars Eden Hazard and Kevin De Bruyne on the sidelines for Roberto Martinez's Red Devils.