Chelsea boss Jose Mourinho concedes their title defence could be over after defeat to Southampton.
Manchester City are now 10 points ahead.
"To be champions will be very difficult. Ten points (to) Man City, maybe tomorrow 11 points (to) Man United," Mourinho said.
"In football it's not impossible, but I think very difficult. Top four is completely - I don't say easy - but doable."
On the dissent from the supporters, Mourinho said: "If they have some negative reaction, I would do the same, because the results are not the results that we want."