Terry has been banned for four games and fined £220,000 by the FA for racially abusing Anton Ferdinand.
But Di Matteo is convinced the Chelsea skipper will only have his mind on getting three points this lunchtime.
The Blues chief said: "John has all the experience in the world to deal with the big game we are playing.
"He likes to focus on the football, that's all I have to be concerned about."
Di Matteo added: "I've spoken to him as I do on a regular basis with my players. I'm not going to tell you my team, but he's available.
"He's an experienced player who has played many games before in difficult circumstances and environments. If selected, I don't think there will be a problem.
"All I can judge is his professionalism when he's here at the club. That's spot-on. He's always one of the first in. He works hard and has been a wonderful servant for this club professionally.
"He's certainly shown over the years he puts his body on the line for the club and the team."