Drogba made one and scored one before the break, before sealing the win with another strike in the second half.
Valencia came with a reputation for attacking play but apart from an early Ramos Jordi Alba effort which hit a post this was to be Chelsea’s night.
Poor defending from the Spanish visitor’s contributed towards the host’s racing into a two goal lead by the 22nd minute.
The Spaniards have now played eight Champions League matches against English clubs and failed to win any of them.
Referee: Gianluca Rocchi (ITA)
Venue: Stamford Bridge
TRIBAL ASKS: Is the dropping of Lampard to the bench a sign of things to come under Villas-Boas?
Yellow cards: Romeu (CHE), Costa (VAL)