Manchester City ace Kevin De Bruyne has been ruled out of the Manchester derby in the EFL Cup fourth round with a calf injury.
The Belgian picked up his injury in the 1-1 draw with Southampton and was substituted at half-time in the game on Sunday.
The 25-year-old is out of Wednesday night's clash at Old Trafford and is also expected to miss City's trip to West Bromwich Albion on Sunday.