Sean Dyche's men are now without a win in seven league games and slipped a place to eighth in the table.
But Defour is adamant the tide will turn after another positive performance against the 20-times champions.
“I think so. Definitely," said the Clarets' midfielder, who turned in another polished performance against the club that coveted his services almost a decade ago.
“It's just small details. We just have to do it what we always do and some point we're going to get that win.
“It's not like we are playing badly. You could see that the players might have been in a dip. I think we're still playing well but the margins are very tight in the Premier League."