Keane has endured a difficult first season at Everton as the Merseysiders have struggled and Lowton says he will win over the doubting fans.
“It'll be good to see Keano and play against him," said the right-back. “But once the game starts, it's down to business and hopefully we can get one over them.
“The move didn't quite work out straight away and the club didn't start how they wanted to do. It would have been tough going in there when they were not doing well.
“I've seen how good he is and once he gets a run in the team, he'll do well. I think their fans will be delighted when they see how good he is."