The Italy No1 was visibly upset over the decision by coach Alberto Zaccheroni.
"I don't know if this will be my last game," he declared to Sky Sport. "Today I didn't take kindly to sitting out as I never thought I'd be at the final day without taking part.
Buffon was then probed as to whether he could be tempted in moving to Manchester City over the summer.
"I really don't know," he added.
"These issues really don't mean a lot right now given the problems the club has faced this season."