Vincenzo Montella will take charge of Roma for the first time.
"The problem is, we don't know what Montella's Roma will be like. I do know the new Coach put many goals past me during his playing career. He was a great striker and I'm sure he'll be just as effective in his new job. It's a huge opportunity for him.
"Claudio Ranieri took a tough decision by resigning. It does him credit that he opted to take all the responsibility on his shoulders," said Malesani.
"Roma didn't deserve to lose against Genoa and up until they were 3-0 up, it was one of their best performances of the season. Now Ranieri's resignation forces the players to react and it won't be easy for us.
"Motivation plays a big part in football, so Francesco Totti and his teammates know they are in debt to their fans. They'll do everything to avoid letting them down again."