The Catalan giants take on City in the Champions League Round of 16 with the first leg taking place at the Etihad Stadium on February 18 and despite the English club competing in this stage if the competition for the first time, Iniesta is aware just how dangerous they are.
"We know Manchester City and they are powerful, especially this season," he told the Spanish media.
"To defeat the English, it is necessary that we are at our best.
"We have two hard matches. The danger against City is not only the physical power of English clubs but also the good touchline team with (Manuel) Pellegrini on the bench.
"But we respect the rivals and we are prepared to fight."
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