Real Madrid, who face lowly Malaga in their final game, are at home to Athletic Bilbao, while Barca face a testing trip to Sevilla before completing their season against second-bottom Real Valladolid at the Nou Camp.
Both of the top two will be favourites to win on the final weekend, which makes what happens in the next four days potentially crucial.
"Against Sevilla it will be a difficult game. With the players we have we must be calm, but not relaxed. It will be a key game, and all the time we are getting closer to the end of the season," said Alves.
"We need to win the six points that remain to reach our objective. This is a very tough league, and in another season we would already have won it."