Barcelona coach Ernresto Valverde admits an injury to Sergio Busquets is a blow.
The midfielder broke down in victory over Champions League opponents Chelsea.
Valverde said: "It's not the first time he has been unavailable and we do have other players; Rakitic has played well there before.
"But Sergio is the best around in that position and it's hard to replace him. Losing players is never good, and Busquets is key to linking defence and attack and pressing the other team. Not having Luis Suárez could be a problem."