Messi is out for two months with a hamstring injury.
Freixa said: "The team is always 'Messi-dependent' because it's impossible not to be with the best player in the world. People talk about it like it's something bad but it's a good thing.
"We've improved this weakness now. The team have other resources and it is performing at a great level."
He added: "We are utterly confident that he'll recover in two months and be the best player in the world.
"If this had to happen it's happened at an extraordinary time, leading the league and qualified in the Champions League, and when the best player in the world gets back we'll be ready to fight for all the titles. Any problems? None."
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