Mourinho is expected to return to Chelsea after his split from Real was confirmed this week.
"Let's see what happens without Mourinho, but I am convinced that Madrid will continue to win titles with or without Mourinho," said Xavi.
"Mourinho's departure is a significant loss for the La Liga.
"He is an important coach on the global scene.
"He is a controversial coach. Always gave us extra motivation. I do not know if we (Barca) will miss him or not."