The England skipper is still being investigated for alleged racism towards Anton Ferdinand following the October 23 loss to QPR but Villas-Boas says he is fine to take on Blackburn Rovers this weekend after being omitted for the midweek Champions League draw with RacingGenk.
"I believe he is in the right frame of mind to play, yes," said the Portuguese tactician.
"We always believe it to be like that. He does not look distracted to us.
"I think John has been involved on all Premiership games. He's our captain, one of the best defenders in the world, and his talent is unquestionable. So, with the talent he is, he's always up for selection."