Gunners boss Arsene Wenger is fuming about the wrong diagnosis which could wreck his side's title challenge.
Wenger said: "The Dutch FA minimalised the injury. We have found out it is much worse than what they had told us. If a player gets injured with his country he should be sent back to his club to be checked out by their doctors.
"Countries just take your player away for a friendly, give him back and say 'there you go'. This doesn't happen in any other sport. It's a joke and there must be more respect for us."
Van Persie, who has scored eight goals in 11 matches for the Gunners, was hurt during the draw with Italy after a challenge by Giorgio Chiellini.
Dutch medics said he would be out for six weeks with a ligament strain. A new scan discovered three of the four ligaments in his right ankle were ruptured.